Huntingtin aggregates ask to be eaten

Be Loved, Be Prey, Be Eaten

ASK "to be, or not to be?".

“To be, or not to be? That is the question.” William Shakespeare, The Tragedy of Hamlet, Prince of Denmark (1599-1602). Viral infection triggers host defense mechanisms that include the production of type I interferon (IFN) and the induction of apoptosis. Type I IFN, such as IFN-α and IFN-β, establishes the antiviral state to inhibits viral replication within infected cells, whereas apoptosis o...

Differential Effect of HDAC3 on Cytoplasmic and Nuclear Huntingtin Aggregates

Histone deacetylases (HDACs) are potential therapeutic targets of polyglutamine (pQ) diseases including Huntington's disease (HD) that may function to correct aberrant transcriptional deactivation caused by mutant pQ proteins. HDAC3 is a unique class 1 HDAC found in both the cytoplasm and in the nucleus. However, the precise functions of HDAC3 in the two cellular compartments are only vaguely k...

Detection of ubiquitinated huntingtin species in intracellular aggregates

Protein conformation diseases, including polyglutamine (polyQ) diseases, result from the accumulation and aggregation of misfolded proteins. Huntington's disease (HD) is one of nine diseases caused by an expanded polyQ repeat within the affected protein and is hallmarked by intracellular inclusion bodies composed of aggregated N-terminal huntingtin (Htt) fragments and other sequestered proteins...

Ask, and it shall be given you.

OUR Lord returns here in the Sermon on the Mount a second time to speak of prayer. The first time He had spoken of the Father who is to be found in secret, and rewards openly, and had given us the pattern prayer (Matt. vi. 5-15). Here He wants to teach us what in all Scripture is considered the chief thing in prayer: the assurance that prayer will be heard and answered. Observe how He uses word...